3122 Smad2 (86F7) Rabbit mAb #3122

"上海博耀生物销售Smad2 (86F7) Rabbit mAb #3122，CST原装品质，价格优惠，订购Smad2 (86F7) Rabbit mAb #3122，详情请咨询销售

"上海博耀生物销售Smad2 (86F7) Rabbit mAb #3122，CST原装品质，价格优惠，订购Smad2 (86F7) Rabbit mAb #3122，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Smad2 (86F7) Rabbit mAb #3122
货号：3122
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3122S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC	H Mk	Endogenous	60	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Smad2 (86F7) Rabbit mAb detects endogenous levels of total Smad2 protein. No cross reactivity was detected with Smad3.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Trp85 of human Smad2.
抗体背景：

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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