3113 HNF4α (C11F12) Rabbit mAb #3113

"上海博耀生物销售HNF4α (C11F12) Rabbit mAb #3113，CST原装品质，价格优惠，订购HNF4α (C11F12) Rabbit mAb #3113，详情请咨

"上海博耀生物销售HNF4α (C11F12) Rabbit mAb #3113，CST原装品质，价格优惠，订购HNF4α (C11F12) Rabbit mAb #3113，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：HNF4α (C11F12) Rabbit mAb #3113
货号：3113
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3113S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P IF-IC	H	Endogenous	52	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： HNF4α (C11F12) Rabbit mAb detects endogenous levels of total HNF4α protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human HNF4α.
抗体背景：

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY) (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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