3083 Phospho-M-CSF Receptor (Tyr546) Antibody #3083

"上海博耀生物销售Phospho-M-CSF Receptor (Tyr546) Antibody #3083，CST原装品质，价格优惠，订购Phospho-M-CSF Receptor (Tyr5

"上海博耀生物销售Phospho-M-CSF Receptor (Tyr546) Antibody #3083，CST原装品质，价格优惠，订购Phospho-M-CSF Receptor (Tyr546) Antibody #3083，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-M-CSF Receptor (Tyr546) Antibody #3083
货号：3083
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3083S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M	Transfected Only	175	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-M-CSF Receptor (Tyr546) Antibody detects transfected levels of M-CSF receptor only when phosphorylated at Tyr546. This antibody may cross-react with other tyrosine-phosphorylated protein tyrosine kinases.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr546 of human M-CSF receptor. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLC-γ 2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-bFGFR/FGFR1碱性成纤维细胞生长因子受体1抗体
Anti-PEG10肝癌高表达基因抗体
ab102801/Anti-CTBS antibody
Anti-MLH1/hMLH 1错配修复蛋白1抗体
Anti-ILK-1整合素连接激酶-1抗体
Anti-JAK2蛋白质酪氨酸激酶JAK2抗体
Anti-Cyclin C周期素C抗体
Anti-BTG2/TIS21B细胞迁移基因2抗体
ab101375/Anti-ANKHD1 antibody
ab103122/Anti-Cer1 antibody
ab103810/Anti-COL9A3 antibody
Anti-GJC2/Connexin 47间隙连接蛋白47抗体
Anti-PCDHB15/PCDHB22原钙粘蛋白15抗体
ab102978/Anti-B4GALT2 antibody
ab103856/Anti-DHRS13 antibody
Anti-SP-B肺表面活性蛋白B抗体"
本页产品地址：http://www.geilan.com/sell/show-3244834.html