3073 Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb #3073

"上海博耀生物销售Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb #3073，CST原装品质，价格优惠，订购Phospho-c-Kit (Tyr703) (D1

"上海博耀生物销售Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb #3073，CST原装品质，价格优惠，订购Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb #3073，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb #3073
货号：3073
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3073P	40 ul (4 western blots)	询价
3073S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Endogenous	145	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb detects endogenous levels of c-Kit only when phosphorylated at Tyr703. This antibody may cross-reacts with other tyrosine-phosphorylated PTKs.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr703 of human c-Kit.
抗体背景：

c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors (1,2). It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells (3). Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL (4). Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders (5), and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors (6). Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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