3066 Phospho-IRS-1 (Tyr1222) Antibody #3066

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"上海博耀生物销售Phospho-IRS-1 (Tyr1222) Antibody #3066，CST原装品质，价格优惠，订购Phospho-IRS-1 (Tyr1222) Antibody #3066，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IRS-1 (Tyr1222) Antibody #3066
货号：3066
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3066S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	R (H) (M)	Transfected Only	180	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IRS-1 (Tyr1222) Antibody detects transfected levels of IRS-1 only when phosphorylated at Tyr1222. The antibody may cross-react with other activated receptor tyrosine kinases (RTKs) and docking proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1222 of human IRS-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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