3050 LKB1 (27D10) Rabbit mAb #3050

"上海博耀生物销售LKB1 (27D10) Rabbit mAb #3050，CST原装品质，价格优惠，订购LKB1 (27D10) Rabbit mAb #3050，详情请咨询销售

"上海博耀生物销售LKB1 (27D10) Rabbit mAb #3050，CST原装品质，价格优惠，订购LKB1 (27D10) Rabbit mAb #3050，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：LKB1 (27D10) Rabbit mAb #3050
货号：3050
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3050S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H R Mk	Endogenous	54	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： LKB1 (27D10) Rabbit mAb detects endogenous levels of LKB1 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human LKB1.
抗体背景：

LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites, 
including human LKB1 at Ser31/325/428 and Thr189/336/363 (5).Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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