3035 NF-κB1 p105/p50 Antibody #3035

"上海博耀生物销售NF-κB1 p105/p50 Antibody #3035，CST原装品质，价格优惠，订购NF-κB1 p105/p50 Antibody #3035，详情请咨询

"上海博耀生物销售NF-κB1 p105/p50 Antibody #3035，CST原装品质，价格优惠，订购NF-κB1 p105/p50 Antibody #3035，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：NF-κB1 p105/p50 Antibody #3035
货号：3035
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3035P	40 ul (4 western blots)	询价
3035S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP ChIP	H Mk	Endogenous	50 Active form. 120 Precursor.	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  ChIP=Chromatin IP
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： NF-kappaB p105/p50 Antibody detects endogenous levels of the precurser protein p105 and its cleavage product p50.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids at the amino-terminus of human NF-kappaB p105.
抗体背景：

Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus (9-11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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