3042 MAPKAPK-2 Antibody #3042

"上海博耀生物销售MAPKAPK-2 Antibody #3042，CST原装品质，价格优惠，订购MAPKAPK-2 Antibody #3042，详情请咨询销售人员！产品

"上海博耀生物销售MAPKAPK-2 Antibody #3042，CST原装品质，价格优惠，订购MAPKAPK-2 Antibody #3042，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MAPKAPK-2 Antibody #3042
货号：3042
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3042P	40 ul (4 western blots)	询价
3042S	100 ul (10 western blots)	询价
3042L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP F	H M R Mk (Hm)	Endogenous	47, 49 (Phosphorylated).	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MAPKAPK-2 Antibody detects endogenous levels of total MAPKAPK-2 protein. This antibody does not cross-react with MAPKAPK-3 or -5.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal region of human MAPKAPK-2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK (1). Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay (2). Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2 (2). Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2 (2).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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