3025 Insulin Receptor β (4B8) Rabbit mAb #3025

"上海博耀生物销售Insulin Receptor β (4B8) Rabbit mAb #3025，CST原装品质，价格优惠，订购Insulin Receptor β (4B8) Rabbit

"上海博耀生物销售Insulin Receptor β (4B8) Rabbit mAb #3025，CST原装品质，价格优惠，订购Insulin Receptor β (4B8) Rabbit mAb #3025，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Insulin Receptor β (4B8) Rabbit mAb #3025
货号：3025
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3025S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R	Endogenous	95	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Insulin Receptor beta (4B8) Rabbit mAb detects endogenous levels of total insulin receptor β. It does not cross-react with IGF-IR β.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr999 of human insulin receptor β.
抗体背景：

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab101358/Anti-GALNT12 antibody
Anti-PDGF-B血小板源性生长因子-B抗体
ab101996/Anti-C3IP1 antibody
ab103453/Anti-GPR180 antibody
ab103828/Anti-CNPY2 antibody
Anti-NLGN2神经连接蛋白2抗体
ab103957/Anti-CMTM7 antibody
Anti-Leptin receptor(long)瘦素受体抗体（长）
ab103548/Anti-beta Actin antibody
ab101939/Anti-Glucose 6 phosphate isomerase antibody
Anti-Mesothelin间皮素抗体
ab102815/Anti-GAA antibody
ab101361/Anti-ARHGAP9 antibody
ab103005/Anti-eRF3B/GSPT2 antibody
ab103848/Anti-Cathepsin S antibody
Anti-Nurr1核受体相关因子-1抗体"
本页产品地址：http://www.geilan.com/sell/show-3244794.html