3027 IGF-I Receptor β Antibody #3027

"上海博耀生物销售IGF-I Receptor β Antibody #3027，CST原装品质，价格优惠，订购IGF-I Receptor β Antibody #3027，详情请咨

"上海博耀生物销售IGF-I Receptor β Antibody #3027，CST原装品质，价格优惠，订购IGF-I Receptor β Antibody #3027，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IGF-I Receptor β Antibody #3027
货号：3027
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3027S	100 ul (10 western blots)	询价
3027L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P	H M R Mk	Endogenous	95	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IGF-I Receptor beta Antibody detects endogenous levels of IGF-IR beta. It does not cross-react with insulin receptor.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal residues of human IGF-IR beta. Antibodies are purified by protein A andd peptide affinity chromatography.
抗体背景：

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab1001/Anti-Dopamine antibody
ab103172/Anti-CD229 antibody
Anti-IL-28R白细胞介素28受体抗体
Anti-BNP脑钠素/利钠肽抗体
ab103989/Anti-GPATCH3 antibody
ab104152/Anti-GART antibody
ab10369/Anti-Eotaxin antibody
Anti-CaMK2a/CaMKII钙/钙调素依赖蛋白激酶2α抗体
Anti-PAX9配对盒基因9抗体
Anti-ALK/CD246间变型淋巴瘤激酶抗体
Anti-TLR2/CD282Toll样受体2抗体
Anti-IL-13白介素13抗体
Anti-ATF1活化转录因子1抗体
ab103986/Anti-ANKMY2 antibody
ab104292/Anti-Epoxide hydrolase antibody
ab103133/Anti-GBE1 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244797.html