3018 IGF-I Receptor β (111A9) Rabbit mAb #3018

"上海博耀生物销售IGF-I Receptor β (111A9) Rabbit mAb #3018，CST原装品质，价格优惠，订购IGF-I Receptor β (111A9) Rabbit

"上海博耀生物销售IGF-I Receptor β (111A9) Rabbit mAb #3018，CST原装品质，价格优惠，订购IGF-I Receptor β (111A9) Rabbit mAb #3018，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IGF-I Receptor β (111A9) Rabbit mAb #3018
货号：3018
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3018S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	95	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IGF-I Receptor beta (111A9) Rabbit mAb detects endogenous levels of total IGF-IR beta protein. It does not cross-react with insulin receptor.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal residues of human IGF-IR beta.
抗体背景：

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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