2947 p21 Waf1/Cip1 (12D1) Rabbit mAb #2947

"上海博耀生物销售p21 Waf1/Cip1 (12D1) Rabbit mAb #2947，CST原装品质，价格优惠，订购p21 Waf1/Cip1 (12D1) Rabbit mAb #2947

"上海博耀生物销售p21 Waf1/Cip1 (12D1) Rabbit mAb #2947，CST原装品质，价格优惠，订购p21 Waf1/Cip1 (12D1) Rabbit mAb #2947，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：p21 Waf1/Cip1 (12D1) Rabbit mAb #2947
货号：2947
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2947P	40 ul (4 western blots)	询价
2947S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IF-IC F	H Mk	Endogenous	21	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： p21 Waf1/Cip1 (12D1) Rabbit mAb detects endogenous levels of total p21 protein. The antibody does not cross-react with other CDK inhibitors.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human p21.
抗体背景：

The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S (1). However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D (2). The carboxy-terminal region of p21 is sufficient to bind and inhibit PCNA, a subunit of DNA polymerase, and may coordinate DNA replication with cell cycle progression (3). Upon UV damage or during cell cycle stages when cdc2/cyclin B or CDK2/cyclin A are active, p53 is phosphorylated and upregulates p21 transcription via a p53-responsive element (4). Protein levels of p21 are downregulated through ubiquitination and proteasomal degradation (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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