2863 Plectin-1 Antibody #2863

"上海博耀生物销售Plectin-1 Antibody #2863，CST原装品质，价格优惠，订购Plectin-1 Antibody #2863，详情请咨询销售人员！产品

"上海博耀生物销售Plectin-1 Antibody #2863，CST原装品质，价格优惠，订购Plectin-1 Antibody #2863，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Plectin-1 Antibody #2863
货号：2863
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2863P	40 ul (4 western blots)	询价
2863S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H Mk	Endogenous	400-500	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Plectin-1 Antibody detects endogenous levels of total plectin-1 protein. The antibody is expected to cross-react with all isoforms of plectin-1 based on the sequence of the immunogenic peptide.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the central sequence of human plectin-1.
抗体背景：

Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules (1). Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering (1,2). Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 (3,4). Plectin is also involved in the regulation of cytokeratin architecture and cell stress response (4), signaling through the chemokine receptor CXCR4 (5) and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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