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2859 Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859

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价格:电议

所在地:上海

型号:2859

更新时间:2013-07-28

浏览次数:654

公司地址:

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产品简介

"上海博耀生物销售Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,CST原装品质,价格优惠,订购Phospho-IκBα (Ser32) (14D4

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"上海博耀生物销售Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,CST原装品质,价格优惠,订购Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,详情请咨询销售人员!
产品详细参数如下>>>>

产品名称:Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859
货号:2859
品牌:CST(cell signaling)
抗体来源:Rabbit
克隆类型: Monoclonal
规格:
No. Size Price
2859P 40 ul (4 western blots) 询价
2859S 100 ul (10 western blots) 询价
2859L 300 ul (30 western blots) 询价

抗体应用:
Applications Reactivity Sensitivity MW (kDa) Isotype
W IP H M R Mk (B) (Dg) (Pg) (GP) Endogenous 40 Rabbit IgG
Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine  Dg=Dog  Pg=Pig  GP=Guinea Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度: Phospho-IκBα (Ser32) (14D4) Rabbit mAb detects endogenous levels of IκBα only when phosphorylated at Ser32.
来源及纯化方法: Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser32 of human IκBα.
抗体背景:

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).

关键词:CST,抗体,一抗{byao_back}{byao_back2}

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