产品简介
"上海博耀生物销售Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,CST原装品质,价格优惠,订购Phospho-IκBα (Ser32) (14D4
产品说明
"上海博耀生物销售
Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,CST原装品质,价格优惠,订购
Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859,详情请咨询销售人员!
产品详细参数如下>>>>
产品名称:Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859
货号:2859
品牌:CST(cell signaling)
抗体来源:Rabbit
克隆类型:
Monoclonal
规格:
| No. |
Size |
Price |
| 2859P |
40 ul (4 western blots) |
询价 |
| 2859S |
100 ul (10 western blots) |
询价 |
| 2859L |
300 ul (30 western blots) |
询价 |
抗体应用:
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Isotype |
| W IP |
H M R Mk (B) (Dg) (Pg) (GP) |
Endogenous |
40 |
Rabbit IgG |
Applications Key:
W=Western Blotting
IP=Immunoprecipitation
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
B=Bovine
Dg=Dog
Pg=Pig
GP=Guinea Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度:
Phospho-IκBα (Ser32) (14D4) Rabbit mAb detects endogenous levels of IκBα only when phosphorylated at Ser32.
来源及纯化方法:
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser32 of human IκBα.
抗体背景:
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).
关键词:CST,抗体,一抗{byao_back}{byao_back2}
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