2857 Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb #2857

"上海博耀生物销售Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb #2857，CST原装品质，价格优惠，订购Phospho-DUSP1/MKP1 (Se

"上海博耀生物销售Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb #2857，CST原装品质，价格优惠，订购Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb #2857，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb #2857
货号：2857
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2857S	100 ul (10 western blots)	询价
2857L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Endogenous	40	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb detects endogenous levels of DUSP1 only when phosphorylated at serine 359.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser359 of human DUSP1.
抗体背景：

MAP kinases are inactivated by a family of dual-specificity protein phosphatases (DUSP) that differ in their substrate specificity, tissue distribution, inducibility by extracellular stimuli and cellular localization. DUSP1/MKP1 (MAP Kinase phosphatase 1) is primarily localized in the nucleus, and has broad substrate specificity towards p44/42 MAPK, p38 MAPK and SAPK/JNK (1-3). DUSP1's transcription and activity are tightly regulated. First, DUSP1 is transcriptionally induced through p44/42 MAPK, p53 and Jak2 (2,4,5). Second, DUSP1 is phosphorylated by p44/42 MAPK at Ser359 and Ser364 in its carboxy-terminal region, which inhibits DUSP1 degradation through the ubiquitin pathway (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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