2766 PKR (N216) Antibody #2766

"上海博耀生物销售PKR (N216) Antibody #2766，CST原装品质，价格优惠，订购PKR (N216) Antibody #2766，详情请咨询销售人员！产

"上海博耀生物销售PKR (N216) Antibody #2766，CST原装品质，价格优惠，订购PKR (N216) Antibody #2766，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PKR (N216) Antibody #2766
货号：2766
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2766S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	74	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PKR (N216) Antibody detects endogenous levels of total PKR protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human PKR. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Protein kinase R (PKR) is transcriptionally induced by interferon and activated by double-stranded RNA (dsRNA). PKR inhibits translation initiation through phosphorylation of the α subunit of the initiation factor eIF2 (eIF2α) and also controls the activation of several transcription factors, such as NF-κB, p53, and the Stats. In addition, PKR mediates apoptosis induced by many different stimuli, such as LPS, TNF-α, viral infection, and serum starvation (1,2). Activation of PKR by dsRNA results in PKR dimerization and autophosphorylation of Thr446 and Thr451 in the activation loop. Substitution of threonine for alanine at position 451 completely inactivated PKR, while a mutant with a threonine to alanine substitution at position 446 was partially active (3). Research studies have implicated PKR activation in the pathologies of neurodegenerative diseases, including Alzheimer's disease (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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