2806 WAVE-3 Antibody #2806

"上海博耀生物销售WAVE-3 Antibody #2806，CST原装品质，价格优惠，订购WAVE-3 Antibody #2806，详情请咨询销售人员！产品详细参

"上海博耀生物销售WAVE-3 Antibody #2806，CST原装品质，价格优惠，订购WAVE-3 Antibody #2806，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：WAVE-3 Antibody #2806
货号：2806
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2806S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk	Endogenous	65-70	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： WAVE-3 Antibody detects endogenous levels of total WAVE-3 protein. The antibody does not cross-react with WAVE-1 or WAVE-2.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the central sequence of human WAVE-3. Antibodies are purified using protein A and peptide affinity chromatography.
抗体背景：

Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality (2,3). Loss of WASP results in immune system defects and fewer immune cells (4). WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain (5). WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system (6). Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kinase (MAPK) pathway (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab101568/Anti-Bcl2 antibody
ab10035/Anti-Corticotropin Releasing Factor antibody
Anti-CIDEB促进凋亡基因抗体
Anti-beta-Amyloid(35-42)β淀粉样肽/Aβ42抗体
ab102115/Anti-Calumenin antibody
ab103587/Anti-ATP2C1 antibody
ab101900/Anti-ATR antibody
Anti-MTNR1B褪黑素受体1B抗体
Anti-Plakophilin 2桥粒斑菲素蛋白2抗体
Anti-MYBPC1肌球蛋白结合蛋白C抗体
Anti-c-fosc-fos抗体
Anti-CDK5周期素依赖性激酶5抗体
ab101976/Anti-C9orf152 antibody
ab10287/Anti-ERp57 antibody
Anti-TGF beta R2/TGFBR2转移生长因子β受体2抗体（TGF-βRⅡ，TGFβRⅡ）
Anti-MICA/MHC IMHC I类链相关蛋白A/组织相容性复合物1抗体"
本页产品地址：http://www.geilan.com/sell/show-3244602.html