2763 MESDC2 (C22F5) Rabbit mAb #2763

"上海博耀生物销售MESDC2 (C22F5) Rabbit mAb #2763，CST原装品质，价格优惠，订购MESDC2 (C22F5) Rabbit mAb #2763，详情请咨询

"上海博耀生物销售MESDC2 (C22F5) Rabbit mAb #2763，CST原装品质，价格优惠，订购MESDC2 (C22F5) Rabbit mAb #2763，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MESDC2 (C22F5) Rabbit mAb #2763
货号：2763
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2763S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	25, 26	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MESDC2 (C22F5) Rabbit mAb detects endogenous levels of total MESDC2 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant human MESDC2 protein.
抗体背景：

Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7 (1). MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6 (2). MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling (3-5). The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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