2747 c-Cbl Antibody #2747

"上海博耀生物销售c-Cbl Antibody #2747，CST原装品质，价格优惠，订购c-Cbl Antibody #2747，详情请咨询销售人员！产品详细参数

"上海博耀生物销售c-Cbl Antibody #2747，CST原装品质，价格优惠，订购c-Cbl Antibody #2747，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：c-Cbl Antibody #2747
货号：2747
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2747S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IF-IC	H M R Mk (B)	Endogenous	120	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： This antibody detects endogenous levels of total c-Cbl protein. The antibody may also cross-react with Cbl-b protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human c-Cbl. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells (1,2). c-Cbl is rapidly tyrosine-phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol-3 kinase, Crk, and 14-3-3 proteins (3,4). c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain (TKB) and a C3HC4 RING finger motif. The TKB recognizes phosphorylated tyrosines on activated receptor tyrosine kinases (RTKs) as well as other nonreceptor tyrosine kinases. The RING finger motif recruits ubiquitin-conjugating enzymes. These two domains are primarily responsible for the ubiquitin ligase activity of c-Cbl and downregulation of RTKs (3). Research studies have indicated that in human cancer tissues, c-Cbl is frequently tyrosine-phosphorylated in a tumor-specific manner (5). Phosphorylation of Tyr731 of c-Cbl provides a docking site for downstream signaling components such as p85 and Fyn (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-BCHE (NT)丁酰胆碱酯酶抗体(N端)
Anti-BK channelBK通道蛋白抗体
Anti-Junctophilin 3连接蛋白JPH3抗体
Anti-BGP/Osteocalcin骨保护蛋白/骨钙素抗体
Anti-TTF-1/NKX2-1甲状腺核转录因子-1抗体
ab102665/Anti-GCNT1 antibody
ab10285/Anti-Endomorphin 1 antibody
Anti-Vimentin波形蛋白抗体
Anti-SKP2/skp2 p45细胞S期激酶相关蛋白2抗体
ab101606/Anti-GPCR GPR26 antibody
ab102554/Anti-Casein Kinase 1 gamma 2 antibody
Anti-TGF Beta R1/TGFBR1转移生长因子β受体1抗体（TGF-βRⅠ，TGFβRⅠ）
ab101957/Anti-DRGX antibody
ab102561/Anti-C17orf75 antibody
ab103694/Anti-FA40B antibody
ab100931/Anti-BACH2 antibody"
本页产品地址：http://www.geilan.com/sell/show-3243802.html