2696 Phospho-B-Raf (Ser445) Antibody #2696

"上海博耀生物销售Phospho-B-Raf (Ser445) Antibody #2696，CST原装品质，价格优惠，订购Phospho-B-Raf (Ser445) Antibody #2696

"上海博耀生物销售Phospho-B-Raf (Ser445) Antibody #2696，CST原装品质，价格优惠，订购Phospho-B-Raf (Ser445) Antibody #2696，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-B-Raf (Ser445) Antibody #2696
货号：2696
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2696P	40 ul (4 western blots)	询价
2696S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk (C) (Dg)	Endogenous	86	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  C=Chicken  Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-B-Raf (Ser445) Antibody detects endogenous levels of B-Raf when phosphorylated at serine 445.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a phospho synthetic peptide corresponding to residues surrounding serine 445 of human B-Raf. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

A-Raf, B-Raf, and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway (1). Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491, Ser494, Ser497, and Ser499 (2). p21-activated protein kinase (PAK) has been shown to phosphorylate c-Raf at Ser338 and the Src family phosphorylates Tyr341 to induce c-Raf activity (3,4). Ser338 of c-Raf corresponds to similar sites in A-Raf (Ser299) and B-Raf (Ser445), although this site is constitutively phosphorylated in B-Raf (5). Inhibitory 14-3-3 binding sites on c-Raf (Ser259 and Ser621) can be phosphorylated by Akt and AMPK, respectively (6,7). While A-Raf, B-Raf, and c-Raf are similar in sequence and function, differential regulation has been observed (8). Of particular interest, B-Raf contains three consensus Akt phosphorylation sites (Ser364, Ser428, and Thr439) and lacks a site equivalent to Tyr341 of c-Raf (8,9). Research studies have shown that the B-Raf mutation V600E results in elevated kinase activity and is commonly found in malignant melanoma (10). Six residues of c-Raf (Ser29, Ser43, Ser289, Ser296, Ser301, and Ser642) become hyperphosphorylated in a manner consistent with c-Raf inactivation. The hyperphosphorylation of these six sites is dependent on downstream MEK signaling and renders c-Raf unresponsive to subsequent activation events (11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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