2695 IKKγ (DA10-12) Mouse mAb #2695

"上海博耀生物销售IKKγ (DA10-12) Mouse mAb #2695，CST原装品质，价格优惠，订购IKKγ (DA10-12) Mouse mAb #2695，详情请咨询

"上海博耀生物销售IKKγ (DA10-12) Mouse mAb #2695，CST原装品质，价格优惠，订购IKKγ (DA10-12) Mouse mAb #2695，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IKKγ (DA10-12) Mouse mAb #2695
货号：2695
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2695S	100 ul (20 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H R	Endogenous	50	Mouse IgG1

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IKKγ (DA10-12) Mouse mAb detects endogenous levels of total IKKγ protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with full length human GST-IKKγ protein.
抗体背景：

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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