2707 Zap-70 (136F12) Rabbit mAb (Alexa Fluor 647 Conjugate) #2707

"上海博耀生物销售Zap-70 (136F12) Rabbit mAb (Alexa Fluor 647 Conjugate) #2707，CST原装品质，价格优惠，订购Zap-70 (136F12

"上海博耀生物销售Zap-70 (136F12) Rabbit mAb (Alexa Fluor 647 Conjugate) #2707，CST原装品质，价格优惠，订购Zap-70 (136F12) Rabbit mAb (Alexa Fluor 647 Conjugate) #2707，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Zap-70 (136F12) Rabbit mAb (Alexa Fluor 647 Conjugate) #2707
货号：2707
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2707S	100 ul (50 tests)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
F	H	Endogenous	70	Rabbit IgG

Applications Key:  F=Flow Cytometry
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Zap-70 (136F12) Rabbit mAb (Alexa Fluor^® 647 Conjugate) detects endogenous levels of total Zap-70 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino-terminus of human Zap-70. The antibody was conjugated to Alexa Fluor^® 647 under optimum conditions with an F/P ratio of 2-6. The Alexa Fluor^® 647 dye is maximally excited by red light (e.g. 633 nm He-Ne laser). Antibody conjugates of the Alexa Fluor^® 647 dye produce bright far-red-fluorescence emission, with a peak at 665 nm.
抗体背景：

The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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