2693 p75NTR Antibody #2693

"上海博耀生物销售p75NTR Antibody #2693，CST原装品质，价格优惠，订购p75NTR Antibody #2693，详情请咨询销售人员！产品详细参

"上海博耀生物销售p75NTR Antibody #2693，CST原装品质，价格优惠，订购p75NTR Antibody #2693，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：p75NTR Antibody #2693
货号：2693
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2693S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H R (M)	Endogenous	75	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： p75NTR Antibody detects endogenous levels of total p75NTR protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human p75NTR. Antibodies are purified by peptide affinity chromatography.
抗体背景：

The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons (2).The p75NTR protein undergoes sequential cleavage similar to APP and Notch. First, α-secretase removes the p75NTR ectodomain, eliminating ligand-mediated signaling. At this point, the membrane-tethered cleavage product can still fine-tune Trk-mediated trophic actions. γ-secretase cleaves within the transmembrane domain to liberate the cytoplasmic tail from its membrane anchor and allow the p75NTR intracellular domain to translocate to the nucleus (3,4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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