2699 CUL4A Antibody #2699

"上海博耀生物销售CUL4A Antibody #2699，CST原装品质，价格优惠，订购CUL4A Antibody #2699，详情请咨询销售人员！产品详细参数

"上海博耀生物销售CUL4A Antibody #2699，CST原装品质，价格优惠，订购CUL4A Antibody #2699，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CUL4A Antibody #2699
货号：2699
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2699S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H Mk	Endogenous	80, 82	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cul4A Antibody detects endogenous levels of total human CUL4A protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. Antibodies are purified by peptide affinity chromatography.
抗体背景：

Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases (1). A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex (2). This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment (2,3). The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression (2), transcription (3), and development (2-6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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