2478 Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb #2478

"上海博耀生物销售Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb #2478，CST原装品质，价格优惠，订购Phospho-VEGF Rec

"上海博耀生物销售Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb #2478，CST原装品质，价格优惠，订购Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb #2478，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb #2478
货号：2478
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2478S	100 ul (10 western blots)	询价
2478L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P IF-IC	H M	Endogenous	230	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-VEGF Receptor-2 (Tyr1175) (19A10) Rabbit mAb detects endogenous levels of VEGFR-2 proteins only when phosphorylated at tyrosine 1175. This antibody may cross-react with VEGFR1.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1175 of human VEGF receptor-2.
抗体背景：

Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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