2477 Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb #2477

"上海博耀生物销售Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb #2477，CST原装品质，价格优惠，订购Phospho-VEGF Rece

"上海博耀生物销售Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb #2477，CST原装品质，价格优惠，订购Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb #2477，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb #2477
货号：2477
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2477S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M	Transfected Only	230	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-VEGF Receptor-2 (Tyr1212) (11A3) Rabbit mAb detects transfected levels of VEGFR-2 only when phosphorylated at tyrosine 1212. The antibody does not cross-react with other phosphorylated receptor tyrosine kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1214 of human VEGF receptor-2.
抗体背景：

Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-FasL/CD178兔抗FasL抗体。
Anti-MIDN中脑核仁蛋白抗体
ab10365/Anti-CINC1 antibody
Anti-Nanog胚胎干细胞关键蛋白抗体
Anti-GAPDH3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）
ab103084/Anti-ARL6IP2 antibody
ab103350/Anti-ERC2 antibody
ab101634/Anti-FLJ21963 antibody
Anti-TDP-43Tar DNA 结合蛋白43抗体
ab101449/Anti-FOXD3 antibody
Anti-SPRR1a/Cornifin A角质蛋白α抗体
ab101964/Anti-C1orf104 antibody
ab101556/Anti-ASAH3L antibody
Anti-AGER晚期糖基化终末产物特异性受体抗体
ab102816/Anti-GSTA3 antibody
Anti-Myelin PLP髓磷酯髓鞘蛋白1抗体"
本页产品地址：http://www.geilan.com/sell/show-3242668.html