2445 VEGF-C Antibody #2445

"上海博耀生物销售VEGF-C Antibody #2445，CST原装品质，价格优惠，订购VEGF-C Antibody #2445，详情请咨询销售人员！产品详细参

"上海博耀生物销售VEGF-C Antibody #2445，CST原装品质，价格优惠，订购VEGF-C Antibody #2445，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：VEGF-C Antibody #2445
货号：2445
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2445S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Recombinant	21 kDa	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： VEGF-C Antibody detects recombinant human VEGF-C protein at various concentrations. This antibody does not cross-react with other VEGF family members.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr189 of human VEGF-C. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. VEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokines. Five VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are generated as a result of alternative splicing from a single VEGF gene (1).The various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cells. VEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signaling. However, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2 (2). Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimers. Receptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylation. Phosphorylated receptors recruit interacting proteins and induce downstream signaling (3). Recently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developed. These new strategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggerated in pathological angiogenesis (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103607/Anti-CCD86 antibody
Anti-PDGF-A血小板源性生长因子A抗体
ab103704/Anti-ERO1LB antibody
ab103642/Anti-CED6 antibody
Anti-CDK1/Cdc2周期素依赖性激酶1抗体
ab103549/Anti-Angiotensinogen antibody
ab100836/Anti-Cofilin (phospho S3) antibody
Anti-NT5C2胞浆-5′-核苷酸酶-Ⅱ抗体
Anti-E-cadherin/CD324上皮钙粘附分子抗体
ab103483/Anti-C21orf128 antibody
Anti-MDM2双微体2癌基因抗体
Anti-PCDHGA7原钙粘蛋白γA7抗体
Anti-MYRIP/SLAC2-CMYRIP蛋白抗体
ab101886/Anti-GRID2 antibody
Anti-PAR-1/Thrombin receptor蛋白酶激活受体-1抗体
Anti-alpha-Synuclein(NT)核突触蛋白-α抗体（N端）"
本页产品地址：http://www.geilan.com/sell/show-3242598.html