2421 Cleaved Notch1 (Val1744) Antibody #2421

"上海博耀生物销售Cleaved Notch1 (Val1744) Antibody #2421，CST原装品质，价格优惠，订购Cleaved Notch1 (Val1744) Antibody #

"上海博耀生物销售Cleaved Notch1 (Val1744) Antibody #2421，CST原装品质，价格优惠，订购Cleaved Notch1 (Val1744) Antibody #2421，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Cleaved Notch1 (Val1744) Antibody #2421
货号：2421
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2421S	100 ul (10 western blots)	询价
2421L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk	Endogenous	110	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cleaved Notch1 (Val1744) Antibody detects endogenous levels of the Notch1 intracellular domain (NICD) only when released by cleavage between Gly1753 and Val1754 (equivalent to Gly1743/Val1744 of murine Notch1). This antibody does not recognize full-length Notch1 or Notch1 cleaved at other positions. This antibody may cross-react with overexpressed cleaved Notch2, 3 and 4.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence at the Val1754 cleavage site in human Notch 1 (equivalent to Val1744 in mouse Notch1). Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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