2315 c-Jun (L70B11) Mouse mAb #2315

"上海博耀生物销售c-Jun (L70B11) Mouse mAb #2315，CST原装品质，价格优惠，订购c-Jun (L70B11) Mouse mAb #2315，详情请咨询销

"上海博耀生物销售c-Jun (L70B11) Mouse mAb #2315，CST原装品质，价格优惠，订购c-Jun (L70B11) Mouse mAb #2315，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：c-Jun (L70B11) Mouse mAb #2315
货号：2315
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2315S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	43, 48	Mouse IgG1

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： c-Jun (L70B11) Mouse mAb detects endogenous levels of total c-Jun protein, regardless of phosphorylation state.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant fragment of c-Jun protein.
抗体背景：

c-Jun is a member of the Jun family containing c-Jun, JunB, and JunD, and is a component of the transcription factor activator protein-1 (AP-1). AP-1 is composed of dimers of Fos, Jun, and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines, and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5), and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival, as well as hypoxia and angiogenesis (8,10). Research studies have implicated c-Jun as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, and rheumatoid arthritis (11,12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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