2254 Toll-like Receptor 9 Antibody #2254

"上海博耀生物销售Toll-like Receptor 9 Antibody #2254，CST原装品质，价格优惠，订购Toll-like Receptor 9 Antibody #2254，详

"上海博耀生物销售Toll-like Receptor 9 Antibody #2254，CST原装品质，价格优惠，订购Toll-like Receptor 9 Antibody #2254，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Toll-like Receptor 9 Antibody #2254
货号：2254
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2254P	40 ul (4 western blots)	询价
2254S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	130	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Toll-like Receptor 9 Antibody detects endogenous levels of total TLR9 protein. Cross reactivity was not detected with other family members at physiological conditions. This antibody is predicted to react with isoforms A and B of human TLR9, based on homology.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly442 of human TLR9 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB, which normally maintains NF-κB in an inactive state by sequestering it in the cytoplasm.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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