2271 Shh/Ihh Antibody #2271

"上海博耀生物销售Shh/Ihh Antibody #2271，CST原装品质，价格优惠，订购Shh/Ihh Antibody #2271，详情请咨询销售人员！产品详细

"上海博耀生物销售Shh/Ihh Antibody #2271，CST原装品质，价格优惠，订购Shh/Ihh Antibody #2271，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Shh/Ihh Antibody #2271
货号：2271
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2271S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	M (H) (R)	Transfected Only	19, (42, 45)	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Shh/Ihh antibody detects both the precursor and mature forms of transfected Shh and transfected Ihh. It is also expected to recognize Shh from cat, dog, chicken and zebra fish based on homology.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu71 of human Shh. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal development. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers (1-2). The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh) and Desert (Dhh), all of which have distinct as well as overlapping roles (3-5). Hh proteins are synthesized as 45 kDa precursors that undergo auto-cleavage to generate a 19 kDa amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. This doubly modified Hh-N peptide is released from cells and responsible for all known Hedgehog signaling activity (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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