2179 c-Cbl (C49H8) Rabbit mAb #2179

"上海博耀生物销售c-Cbl (C49H8) Rabbit mAb #2179，CST原装品质，价格优惠，订购c-Cbl (C49H8) Rabbit mAb #2179，详情请咨询销

"上海博耀生物销售c-Cbl (C49H8) Rabbit mAb #2179，CST原装品质，价格优惠，订购c-Cbl (C49H8) Rabbit mAb #2179，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：c-Cbl (C49H8) Rabbit mAb #2179
货号：2179
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2179P	40 ul (4 western blots)	询价
2179S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H Mk	Endogenous	120	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： c-Cbl (C49H8) Rabbit mAb detects endogenous levels of total c-Cbl protein. The antibody does not cross-react with Cbl-b or Cbl-c proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human c-Cbl.
抗体背景：

The c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells (1,2). c-Cbl is rapidly tyrosine-phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol-3 kinase, Crk, and 14-3-3 proteins (3,4). c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain (TKB) and a C3HC4 RING finger motif. The TKB recognizes phosphorylated tyrosines on activated receptor tyrosine kinases (RTKs) as well as other nonreceptor tyrosine kinases. The RING finger motif recruits ubiquitin-conjugating enzymes. These two domains are primarily responsible for the ubiquitin ligase activity of c-Cbl and downregulation of RTKs (3). Research studies have indicated that in human cancer tissues, c-Cbl is frequently tyrosine-phosphorylated in a tumor-specific manner (5). Phosphorylation of Tyr731 of c-Cbl provides a docking site for downstream signaling components such as p85 and Fyn (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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