2176 HtrA2 Antibody #2176

"上海博耀生物销售HtrA2 Antibody #2176，CST原装品质，价格优惠，订购HtrA2 Antibody #2176，详情请咨询销售人员！产品详细参数

"上海博耀生物销售HtrA2 Antibody #2176，CST原装品质，价格优惠，订购HtrA2 Antibody #2176，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：HtrA2 Antibody #2176
货号：2176
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2176S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk (Dg)	Endogenous	36	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： HtrA2 Antibody detects endogenous levels of the mature form of HtrA2. This antibody is expected to also recognize the unprocessed form of HtrA2. The unprocessed form is detected in cells overexpressing HtrA2.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser335 of HtrA2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins (1). While HtrA2 was orignally identified to be present in either the nucleus (1) or endoplasmic reticulum (2), subsequent studies have shown that it localizes in mitochondria and is released during apoptosis (3-8). HtrA2 is produced as a 50 kDa zymogen that is cleaved to generate a 36 kDa mature protein that exposes an amino terminal motif (AVPS) resembling that of the IAP inhibitor Smac/Diablo (3-8). Like Smac, interaction between HtrA2 and IAP family members, such as XIAP, antagonizes their inhibition of caspase activity and protection from apoptosis (3-8). Interestingly, HtrA2 knock-out mice did not show signs of reduced apoptosis, but rather had a loss of neurons in the striatum and a Parkinson's-like phenotype, suggesting that HtrA2 might have a neuroprotective function (9-11). This activity is associated with the protease activity of HtrA2 (9). Furthermore, research studies have shown that loss of function mutations in the HtrA2 gene are associated with Parkinson's disease (12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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