产品简介
"上海博耀生物销售MEP50 (D56B8) Rabbit mAb #2018,CST原装品质,价格优惠,订购MEP50 (D56B8) Rabbit mAb #2018,详情请咨询销
产品说明
"上海博耀生物销售
MEP50 (D56B8) Rabbit mAb #2018,CST原装品质,价格优惠,订购
MEP50 (D56B8) Rabbit mAb #2018,详情请咨询销售人员!
产品详细参数如下>>>>
产品名称:MEP50 (D56B8) Rabbit mAb #2018
货号:2018
品牌:CST(cell signaling)
抗体来源:Rabbit
克隆类型:
Monoclonal
规格:
| No. |
Size |
Price |
| 2018S |
100 ul (10 western blots) |
询价 |
抗体应用:
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Isotype |
| W IP |
H M R Mk |
Endogenous |
42 |
Rabbit IgG |
Applications Key:
W=Western Blotting
IP=Immunoprecipitation
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度:
MEP50 (D56B8) Rabbit mAb detects endogenous levels of MEP50 protein.
来源及纯化方法:
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino acids surrounding Ser225 of human MEP50.
抗体背景:
MEP50 (methylosome protein 50) is a component of the methylosome, a protein arginine methyltransferase complex that modifies specific arginine residues found in arginine- and glycine-rich regions of some spliceosomal Sm proteins. MEP50 is important for methylosome activity and may regulate the transfer of Sm proteins to the SMN (survival of motor neurons) complex, an early step in the assembly of U snRNPs. Both the methylosome and the SMN complex are essential for the assembly of spliceosomal snRNPs (1).MEP50 is a WD repeat protein that may provide an interface for multiple protein interactions between methylosome proteins. (1). It binds to JBP1, an arginine protein methyltransferase component of the methylosome. MEP50 has been shown to interact with CTD phosphatase FCP1 (CTDP1), a protein that may link the processes of transcriptional elongation and splicing (2), and with SUZ12, a polycomb group protein involved in transcriptional repression (3). JBP1 and MEP50 have also been reported to interact with the methyl-CpG binding protein complex MBD2/NuRD (4).
关键词:CST,抗体,一抗{byao_back}{byao_back2}
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