JN1330 重组人叶酸受体α(FOLR1)

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人叶酸受体α(FOLR1)在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。...

特别提示：包括重组人叶酸受体α(FOLR1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人叶酸受体α(FOLR1)
英文名称：Recombinant Human Folate Receptor alpha
产品货号：JN1330
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Arg25-Ser234在C端含有His标签。

FOLR1质量控制：＞95%(还原性SDS-PAGE)

FOLR1制剂：冻干品

FOLR1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

FOLR1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于FOLR1：
Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

根据您的关注的重组人叶酸受体α(FOLR1)，重组Folate Receptor alpha，重组人叶酸受体α，重组叶酸受体α，重组FOLR1，重组人Folate Receptor alpha，Recombinant Human Folate Receptor alpha，rFOLR1，重组人FOLR1，rhFOLR1，您可能还对以下产品有需求：


JN0221 重组人β-NGF(神经生长因子) 10μg|50μg|500μg|1mg
JN0247 重组人FGF2(碱性成纤维细胞生长因子2) 10μg|50μg|500μg|1mg
JN0352 重组人白介素IL-36α(白细胞介素36α) 10μg|50μg|500μg|1mg
JN0751 重组人ADH7(乙醇脱氢酶4μ) 10μg|50μg|500μg|1mg
JN0909 重组人高迁移率族蛋白1(HMGB1) 10μg|50μg|500μg|1mg
JN1031 重组人STAT6(信号转导子和转录激活子6) 10μg|50μg|500μg|1mg
JN1072 重组人NHP2(核仁蛋白家族A成员2) 10μg|50μg|500μg|1mg

关注重组人叶酸受体α(FOLR1)，重组Folate Receptor alpha，重组人叶酸受体α，重组叶酸受体α，重组FOLR1，重组人Folate Receptor alpha，Recombinant Human Folate Receptor alpha，rFOLR1，重组人FOLR1，rhFOLR1的同时，为您推荐更多您可能感兴趣的产品：



名称：重组人MANF(含His标签)
货号：JN0208
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Leu25-Leu182在C端含有His标签。

MANF质量控制：＞95%(还原性SDS-PAGE)。

MANF制剂：冻干品

MANF保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

MANF复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于MANF：
Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.

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