JN0208 重组人MANF(含His标签)

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人MANF(含His标签)在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。...

特别提示：包括重组人MANF(含His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人MANF(含His标签)
英文名称：Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor
产品货号：JN0208
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物表达系统制备，目的基因编码的Leu25-Leu182在C端含有His标签。

MANF质量控制：＞95%(还原性SDS-PAGE)。

MANF制剂：冻干品

MANF保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

MANF复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于MANF：
Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.

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名称：重组人趋化因子CCL26(Eotaxin-3)
货号：JN0305
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Thr24-Leu94表达纯化而来。

CCL26/Eotaxin-3质量控制：＞95%(还原性SDS-PAGE)。

CCL26/Eotaxin-3制剂：液体

CCL26/Eotaxin-3保存：
收到后请置于-20℃，可稳定保存6个月，避免反复冻融。

关于CCL26/Eotaxin-3：
Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus, but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, CCL26 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.

关注重组人MANF(含His标签)，重组人MANF，重组MANF，rMANF，重组人Mesencephalic astrocyte-derived neurotrophic factor，重组Mesencephalic astrocyte-derived neurotrophic factor，rhMANF，Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor，重组人含His标签，重组含His标签的同时，为您推荐更多您可能感兴趣的产品：

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