JN1583 重组人Glypican 1

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人Glypican 1在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。...

特别提示：包括重组人Glypican 1(GPC1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Glypican 1(GPC1)
英文名称：Recombinant Human Glypican-1
产品货号：JN1583
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp24-Thr529在N端含有His标签。

Glypican 1质量控制：＞95%(还原性SDS-PAGE)

Glypican 1制剂：冻干品

Glypican 1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Glypican 1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Glypican 1：
The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 aa signal sequence, a 507 aa mature segment, and a 28 aa C-terminal prosegment. There are two potential N-linked and four potential O-linked sites for glycosylation or glycanation. There are potentially two heparan sulfate (HS) modifications on GPC1 that could contribute to a native molecular weight of approximately 200 kDa. Mature human GPC1 shares 91% aa identity with mature mouse GPC1. Cells known to express GPC1 include neurons, smooth and skeletal muscle cells, keratinocytes, osteoblasts, Schwann cells, immature dendritic cells, and tumor, plus tumorassociated vascular endothelial cells. The function of GPC1 is complex and varied. As a proteoglycan, it appears to make use of its HS adduct to impact select growth factor activity. This is accomplished by having juxtramembrane HS attachment sites, and a flexible, GPI-linkage.

根据您的关注的重组人Glypican 1(GPC1)，重组人Glypican 1，rhGlypican-1，重组GPC1，重组人Glypican-1，rGPC1，Recombinant Human Glypican-1，rGlypican-1，重组Glypican-1，rhGPC1，重组人GPC1，重组Glypican 1，您可能还对以下产品有需求：



名称：重组人白介素IL-25(白细胞介素25)
货号：JN0355
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，表达蛋白包含序列(Tyr33-Gly177)。

IL-25质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)

IL-25制剂：冻干品

IL-25保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-25复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-25：
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells. Human IL-17E cDNA encodes a 177 amino acid residues precursor protein with a putative 32 amino acid signal peptide. A second isoform of human IL-17E encoding a 161 amino acid precursor protein also exists.

关注重组人Glypican 1(GPC1)，重组人Glypican 1，rhGlypican-1，重组GPC1，重组人Glypican-1，rGPC1，Recombinant Human Glypican-1，rGlypican-1，重组Glypican-1，rhGPC1，重组人GPC1，重组Glypican 1的同时，为您推荐更多您可能感兴趣的产品：


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