HH-5 1,2-二氯乙烷中毒患者血液毒物色谱分析

滕州市浩瀚色谱仪器技术服务有限公司，探讨职业性急性1,2-二氯乙烷(1,2-DCE)中毒患者血中二氯乙烷检测的临床意义。方法选择收治的职业性急性1,2-DCE中毒病例38例,随机对其中12例病例进行血中毒物检测;检测方法为顶空气相色谱-质谱法。结果12例患者中有7例患者在发病6~18h送血标本检出1,2-DCE成份,其中3例同时检出丙酮成份;另外5例在发病24~72h送血检测,均未检出1,2-DCE成份,仅检出丙酮成份,(1例检出二氯甲烷、甲苯,1例检出二硫化碳)。结论急性1,2-DCE中毒患者应早期进行血毒物检测,1,2-DCE阳性对明确病因及临床诊断有重要价值。

1,2-二氯乙烷中毒患者血液毒物色谱分析 图片：


Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning
Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning

Stationary phase: 5% phenyl-methyl polysiloxane
Specification: 60m*0.25mm*0.25um
Model: HH-5
Application: GBZ/T 286-2016 Determination of 1,2-dichloroethane in blood by gas chromatography-mass spectrometry


Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd. explored the clinical significance of detection of dichloroethane in blood of patients with occupational acute 1,2-dichloroethane (1,2-DCE) poisoning. Methods A total of 38 cases of occupational acute 1,2-DCE poisoning were selected. Blood poisoning was detected in 12 cases. The detection method was headspace gas chromatography-mass spectrometry. Results Among the 12 patients, 7 patients were found to have 1,2-DCE in the blood samples from 6 to 18 hours after the onset of symptoms. 3 of them were detected with acetone at the same time. The other 5 patients were tested for blood supply at 24 to 72 hours after the onset. The 1,2-DCE component was detected, and only the acetone component was detected (1 case of dichloromethane, toluene, and 1 case of carbon disulfide). Conclusion Patients with acute 1,2-DCE poisoning should be tested for blood poisoning at an early stage. 1,2-DCE positive is of great value for definite etiology and clinical diagnosis.

Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning