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产品名称:小鼠TNFα重组蛋白
英文名称:Recombinant Mouse TNFα
产品货号:ZN1794
产品规格:100ng
来源:大肠杆菌
特异性:小鼠
应用:WB 阳性对照
形态:冻干粉
纯度:>98%,RP-HPLC&SDS-PAGE
保存条件:-20℃保存 1 年以上,避免反复冻融。
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小鼠TNFα重组蛋白,重组TNFα,rTNFα,TNFα,Recombinant Mouse TNFα,您可能还对以下产品有需求:
名称:重组人白介素IL-36α(白细胞介素36α)
货号:JN0352
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备,目的基因编码的Met1-Phe158表达纯化而来。
IL-36 alpha/IL-1F6质量控制:>95%(还原性SDS-PAGE)。
IL-36 alpha/IL-1F6制剂:冻干品
IL-36 alpha/IL-1F6保存:
冻干蛋白可在-20℃长期保存,室温也可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天。
复溶后建议分装冻存在-20℃,可保存3个月,应避免反复冻融。
IL-36 alpha/IL-1F6复溶:
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存,避免反复冻融。
关于IL-36 alpha/IL-1F6:
Human Interleukin-36α (IL-36α) is a secreted cytokine that belo
ngs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the o
nly IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene ex
pression. im
portantly, IL-36α inhibits PPARγ ex
pression, which may lead to a reduction in adipocyte differentiation suggesting me
tabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an ago
nist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in havin
g a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
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