JN0467 重组人TNF-α

我公司致力于为客户提供高纯度、低成本的活性重组蛋白，包括重组人TNF-α在内的各类受体、细胞因子、生长因子、转录因子、激素、酶、毒性蛋白、病毒抗原等。

北京百奥莱博科技有限公司是一家专业的生物试剂销售公司。公司主要经营血清、抗原、抗体等生物试剂产品，可以为您提供专业的技术服务，以优良的价格、优质的服务、优先的理念，满足客户的各方面的需求，与国内多家企业、单位建立了良好的长期合作关系，拥有较好的企业信誉和品牌形象。 主营产品:血清、抗体、抗原、核酸提取、核酸纯化等生化试剂

特别提示：包括重组人TNF-α(C端His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人TNF-α(C端His标签)
英文名称：Recombinant Human Tumor Necrosis Factor alpha
产品货号：JN0467
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Val77-Leu233在C端含有His标签。

TNF-alpha质量控制：＞95%(还原性SDS-PAGE)

TNF-alpha制剂：冻干品

TNF-alpha保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TNF-alpha复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TNF-alpha：
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α. Synthesis of TNF-α can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. based on these results, many TNF-α mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.


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JN0449 重组人补体C1q和TNF相关蛋白9(C1QTNF9) 10μg|50μg|500μg|1mg
JN2010 重组人NHP2样蛋白1(NHP2L1) 10μg|50μg|500μg|1mg
JN0692 重组人半乳糖凝集素1(Galectin-1) 10μg|50μg|500μg|1mg
JN0838 重组人CGREF1 10μg|50μg|500μg|1mg
JN0873 重组人B细胞连接蛋白(BLNK) 10μg|50μg|500μg|1mg
JN1081 重组人载脂蛋白C2(ApoC2) 10μg|50μg|500μg|1mg
JN1094 重组人ICOS(可诱导T细胞共刺激分子) 10μg|50μg|500μg|1mg

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名称：重组人趋化因子CCL11(Eotaxin)
货号：JN0318
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Gly24-Pro97表达纯化而来。

CCL11/Eotaxin质量控制：＞95%(还原性SDS-PAGE)。

CCL11/Eotaxin制剂：冻干品

CCL11/Eotaxin保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CCL11/Eotaxin复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CCL11/Eotaxin：
C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.

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