特别提示:包括重组人Cerberus-1在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:重组人Cerberus-1
英文名称:Recombinant Human Cerberus 1
产品货号:JN0635
产品规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Thr18-Ala267在C端含有His标签。
Cerberus1质量控制:>95%(还原性SDS-PAGE)
Cerberus1制剂:冻干品
Cerberus1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Cerberus1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Cerberus1:
Cerberus 1 is a secreted glycoprotein that forms disulfide-l
inked homodimers. It is a cytokine member of the DAN domain family of BMP antago
nists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members co
ntain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the o
nset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in respo
nse to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryo
nic left-right polarization, neurulation, and head and heart induction.
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