SC-8025 Dvl-1 (3F12)抗体

抗体 名：Dvl-1 (3F12)抗体

规格：200ug

Santa Cruz是美国也是上zui大的抗体生产厂家，提供抗体种类多达两万多种，几乎覆盖了目前生命科学研究的各个新领域，其每种抗体又有多个克隆可选择，并有对应蛋白标准品及相关产品，为免疫学研究工作提供了大的方便。
产品介绍：

Dvl-1 (3F12)抗体基因信息：

Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3 (1-5). The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein (1,2). Like their Drosophila counterpart, the dishevelled proteins are thought to be involved in embryogenesis (5). Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3ß. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated (6). In Drosophila, Dsh is a component of the frizzled signaling pathway (7). Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway (8).