3346 SEK1 (5C10) Rabbit mAb #3346

"上海博耀生物销售SEK1 (5C10) Rabbit mAb #3346，CST原装品质，价格优惠，订购SEK1 (5C10) Rabbit mAb #3346，详情请咨询销售人

"上海博耀生物销售SEK1 (5C10) Rabbit mAb #3346，CST原装品质，价格优惠，订购SEK1 (5C10) Rabbit mAb #3346，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：SEK1 (5C10) Rabbit mAb #3346
货号：3346
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3346S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk (Dg)	Endogenous	44	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： SEK1 (5C10) Rabbit mAb detects endogenous levels of total SEK1 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues at the amino terminus of human SEK1.
抗体背景：

SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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