3334 RasGRP3 (C33A3) Rabbit mAb #3334

"上海博耀生物销售RasGRP3 (C33A3) Rabbit mAb #3334，CST原装品质，价格优惠，订购RasGRP3 (C33A3) Rabbit mAb #3334，详情请咨

"上海博耀生物销售RasGRP3 (C33A3) Rabbit mAb #3334，CST原装品质，价格优惠，订购RasGRP3 (C33A3) Rabbit mAb #3334，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：RasGRP3 (C33A3) Rabbit mAb #3334
货号：3334
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3334S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M (Mk)	Endogenous	78	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： RasGRP3 (C33A3) Rabbit mAb detects endogenous levels of total RasGRP3 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy teminus of human RasGRP3.
抗体背景：

Lymphocyte activation occurs in part through activation of the Ras signaling pathway following lymphocyte receptor stimulation. The RasGRP family of guanine nucleotide exchange factors (GEFs) catalyzes the exchange of GDP for GTP on Ras family small GTPases, promoting their active GTP-bound form. Diacylglycerol (DAG) or phorbol ester binding to RasGRP family members causes their translocation to the cell membrane and stimulates their activity (1,2). While T-Cells express RasGRP1, B-cells express both RasGRP1 and RasGRP3. RasGRP3 is important in linking B-cell receptor (BCR) activation to Ras signaling (3). In response to BCR stimulation, RasGRP3 is phosphorylated at Thr133 by PKC. This phosphorylation event further activates RasGRP3 in response to DAG, which stimulates PKC activity (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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