3330 PTPA/PPP2R4 Antibody #3330

"上海博耀生物销售PTPA/PPP2R4 Antibody #3330，CST原装品质，价格优惠，订购PTPA/PPP2R4 Antibody #3330，详情请咨询销售人员！

"上海博耀生物销售PTPA/PPP2R4 Antibody #3330，CST原装品质，价格优惠，订购PTPA/PPP2R4 Antibody #3330，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PTPA/PPP2R4 Antibody #3330
货号：3330
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3330S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk	Endogenous	40	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PTPA/PPP2R4 Antibody detects endogenous levels of total PTPA protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human PTPA. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development (1-3). Active protein phosphatase 2A is composed of both structural (A) and catalytic (C) proteins, and its activity relies on interaction with regulatory (B) subunits. An important PP2A regulatory subunit is PP2A phosphatase activator (PTPA), also known as the PP2A activator regulatory subunit 4 (PPP2R4) (4). This PTPA regulatory protein binds ATP and has isomerase (PPIase) activity, suggesting that PP2A regulation involves a change in phosphatase conformation. The addition of ATP (and Mg²⁺) results in a correlated increase in both PP2A activation and PTPA isomerase activity (5). While the exact mechanism is still under consideration, evidence suggests that binding of PTPA to the PP2A A-C dimer produces a conformational change in PP2A that shifts phosphatase substrate specificity from phosphoserine to phosphotyrosine substrates (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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