3321 Phospho-Ras-GRF1 (Ser916) Antibody #3321

"上海博耀生物销售Phospho-Ras-GRF1 (Ser916) Antibody #3321，CST原装品质，价格优惠，订购Phospho-Ras-GRF1 (Ser916) Antibody

"上海博耀生物销售Phospho-Ras-GRF1 (Ser916) Antibody #3321，CST原装品质，价格优惠，订购Phospho-Ras-GRF1 (Ser916) Antibody #3321，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Ras-GRF1 (Ser916) Antibody #3321
货号：3321
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3321S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	M R	Transfected Only	155	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Ras-GRF1 (Ser916) Antibody detects transfected levels of Ras-GRF1 only when phosphorylated at serine 916. This antibody does not cross-react with phosphorylated Ras-GRF2.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding serine 916 of mouse Ras-GRF1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx (1,2). Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity (1,2). Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity (3). Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity (4). It has been reported that Ras-GRF1 also shows GEF activity toward Rac after phosphorylation by the tyrosine kinase Src (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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