3319 MARK1 Antibody #3319

"上海博耀生物销售MARK1 Antibody #3319，CST原装品质，价格优惠，订购MARK1 Antibody #3319，详情请咨询销售人员！产品详细参数

"上海博耀生物销售MARK1 Antibody #3319，CST原装品质，价格优惠，订购MARK1 Antibody #3319，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MARK1 Antibody #3319
货号：3319
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3319S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R	Endogenous	85	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MARK1 Antibody detects endogenous levels of total MARK1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala547 of MARK1. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking (1). The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases was identified based on their ability to phosphorylate microtubule-associated proteins (MAPs) including tau, MAP2 and MAP4 (2-6). MARK proteins phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics (2-4). In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimer's disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death (4). The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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