3316 Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb #3316

"上海博耀生物销售Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb #3316，CST原装品质，价格优惠，订购Phospho-MAPKAPK-2 (Thr222

"上海博耀生物销售Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb #3316，CST原装品质，价格优惠，订购Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb #3316，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb #3316
货号：3316
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3316P	40 ul (4 western blots)	询价
3316S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	49	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb detects endogenous levels of MAPKAPK-2 protein only when phosphorylated at Thr222.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr222 of human MAPKAPK-2.
抗体背景：

In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK (1). Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay (2). Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2 (2). Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2 (2).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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