3293 PHD-2/Egln1 Antibody #3293

"上海博耀生物销售PHD-2/Egln1 Antibody #3293，CST原装品质，价格优惠，订购PHD-2/Egln1 Antibody #3293，详情请咨询销售人员！

"上海博耀生物销售PHD-2/Egln1 Antibody #3293，CST原装品质，价格优惠，订购PHD-2/Egln1 Antibody #3293，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PHD-2/Egln1 Antibody #3293
货号：3293
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3293S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	50	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PHD-2/Egln1 Antibody detects endogenous levels of total PHD-2/Egln1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val226 of human PHD-2/Egln1 protein. Antibodies are purified by peptide affinity chromatography.
抗体背景：

PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) are members of the Egln family of proline hydroxylases. They function as oxygen sensors that catalyze the hydroxylation of HIF on prolines 564 and 402, initiating the first step of HIF degradation through the VHL/ubiquitin pathway (1,2). PHD1 is highly expressed in a wide array of tissues whereas PHD2 and PHD3 are expressed mainly in heart and skeletal muscle (1,3). The mRNA levels of PHD are upregulated by HIF through the hypoxia-response element under low oxygen conditions (4-7). These three enzymes also exhibit different peptide specificity target proteins, PHD1 and PHD2 can hydroxylate both proline 402 and proline 564, but PHD3 can only hydroxylate proline 564 (2,8). In addition to HIF, PHD enzymes have also has been shown to catalyze the hydroxylation of RNA polymerase subunits and myogenin (3,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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