3289 5-Lipoxygenase (C49G1) Rabbit mAb #3289

"上海博耀生物销售5-Lipoxygenase (C49G1) Rabbit mAb #3289，CST原装品质，价格优惠，订购5-Lipoxygenase (C49G1) Rabbit mAb #

"上海博耀生物销售5-Lipoxygenase (C49G1) Rabbit mAb #3289，CST原装品质，价格优惠，订购5-Lipoxygenase (C49G1) Rabbit mAb #3289，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：5-Lipoxygenase (C49G1) Rabbit mAb #3289
货号：3289
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3289S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H (M) (R) (Mk)	Endogenous	78	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： 5-Lipoxygenase (C49G1) Rabbit mAb detects endogenous levels of total 5-lipoxygenase protein. Expression of 5-Lipoxygenasae is very low in most tissues and cell lines, excepting whole blood, bone marrow, lung and macrophage cell lines.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile168 of human 5-lipoxygenase protein.
抗体背景：

5-Lipoxygenase (5-LO, ALOX5) is an important catalytic enzyme responsible for the biosynthesis of leukotriene LTA₄ from arachidonic acid (1,2). Leukotriene synthesis also requires 5-lipoxygenase-activating protein (FLAP, ALOXP), a nuclear membrane-bound protein that binds arachidonic acid and is thought to activate 5-LO. A number of related leukotrienes (i.e. B₄, C₄, D₄) are derived from LTA₄ and together these lipid mediators function in immune reaction regulation. 5-LO is primarily expressed in polymorphonuclear leukocytes, peripheral blood monocytes, macrophages, and mast cells (1,3). Overexpression of 5-LO protein is seen in certain cancer cells and is associated with poor diagnosis (1,4). Depending upon the cell type, 5-LO is localized to either the cytosol or the nucleus of quiescent cells (5). Following stimulation, 5-LO translocates to the nucleus and associates with FLAP to catalyze LTA₄ synthesis (2,3). Phosphorylation of specific residues can regulate 5-LO enzymatic activity. Phosphorylation of 5-LO at Ser523 by PKA family kinases inhibits oxygenase activity (6,7) while MAPKAP2 and ERK family kinase phosphorylation at Ser271 and Ser663 stimulates 5-LO enzymatic activity in vivo (8,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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